OSDD has set up a high throughput open screening facility where researchers can send compounds synthesized by them for screening against TB and Malaria. Three laboratories involved in screening process are CSIR-IIIM (Jammu), CSIR-CDRI (Lucknow), and CSIR-IICT (Hyderabad). Under this, Indian Institute of Integrative Medicine (CSIR–IIIM) has screened 20,000 drug like molecules from Chembridge Database to identify potential anti-TB molecules .Under this initiative CSIR-Central Drug Research Institute (CDRI), Lucknow is involved in the biological screening of H37Rv strains and Indian Institute of Chemical Technology (IICT), Hyderabad is involved in screening against Mycobacterium smegmatis strains. Besides screening the molecules submitted in OSDDChem, CSIR-CDRI is also involved in the screening of 37,000 in-house compounds.

So far 2 molecules have been identified as hits and are under hit to lead phase of the drug discovery pipeline. These projects—Thiophene containing tri-substituted methanes CDRI-S006-830 (CSIR-CDRI) and LAMS (CSIR-IGIB and Jubilant Chemsys) are under progress to optimize these molecules.